The effects of proliferation and differentiation on adipocyte 3T3-L1 by prescriptions and herbs of Taeyang-In and Taeum-In Su-Beom Kim Dept. of Oriental Medicine, Graduate School, Kyung Hee University Seoul, Korea (directed by prof. Il-Byung Song, O.M.D., Ph.D.) In order to know the effect of proliferation and differentiation on edipocyte 3T3-L1 by prescriptions and herbs, Taeyang-In(太陽人)'s Okapijangcheok- tang(五加皮壯脊湯)·Mihudeungsikjang-tang( 藤植腸湯)·Acanthopanacis Cortex( 五加皮 )·Phragmitis Rhi- zoma(蘆根) and Taeum-In(太陰人)'s Taeumjowi-tang (太陰調胃湯)·Cheongsimyonja-tang(淸心蓮子湯)·Cheongpaesagan-tang(淸肺瀉肝湯)·Galkeunbupyong-tang(葛根浮萍湯)· Coicis Semen(薏苡仁)·Rhei Undulati Rhizoma(大黃)·Mori Cortex(桑白皮)·Ulmi Cortex(楡根白皮)·Holotrichia Vermiculus( )·Kalopanaxii Cortex(海桐皮)· Ephedrae Herba(麻黃)·Imperatae Rhizoma(白茅根), were used and had some effects. 1. The proliferation effect of edipocyte 1) At the Taeyang-In(太陽人)'s prescriptions and herbs, Okapijangcheok-tang (五加皮壯脊湯)·Mihudeungsikjang-tang( 藤植腸湯)·Acanthopanacis Cortex(五加皮) have a control effect at the boiling water-extract and ethyl alcohol-extract. Phragmitis Rhizoma(蘆根) have a control effect at the ethyl alcohol-extract. 2) At the Taeyang-In(太陰人)'s prescriptions and herbs, Teum jowi-tang(太陰調胃湯)·Cheongsimyonja-tang(淸心蓮子湯)·Cheongpaesagan-tang(淸肺瀉肝湯)·Galkeunbupyong-tang(葛根浮萍湯) have a control effect at the boiling water-extract and ethyl alcohol-extract. Coicis Semen(薏苡仁)·Rhei Undulati Rhizoma(大黃)·Mori Cortex(桑白皮)·Ulmi Cortex(楡根白皮)·Kalopanaxii Cortex(海桐皮)·Ephedrae Herba(麻黃) of the boiling water-extract., Holotrichia Vermiculus( )·Kalopanaxii Cortex(海桐皮) of ethyl alcohol-extract have a control effect on edipocytes. Rhei Undulati Rhizoma(大黃)·Ulmi Cortex(楡根白皮)·Ephedrae Herba(麻黃) of high-density have a cyto-toxicity. 2. The differentiation effect of edipocyte 1) At the Taeyang-In(太陽人)'s prescriptions and herbs during the natural differentiation, Phragmitis Rhizoma(蘆根) of the boiling water-extract, Okapijangchek-tang(五加皮壯脊湯)·Acanthopanacis Cortex(五加皮) of the ethyl alcohol-extract have a cyto-toxicity on the first-differentiation. 2) At the Taeum-In(太陰人)'s prescriptions and herbs during the natural differentiation, Ulmi Cortex(楡根白皮)·Kalopanaxii Cortex(海桐皮) of the boiling water-extract have a cyto-toxicity on the first-differentiation. Cheongsimyonja-tang(淸心蓮子湯)·Ephedrae Herba(麻黃) of ethyl alcohol-extract have a control effect on the redifferentiation. 3) At the Taeyang-In(太陽人)'s prescriptions and herbs on the first-differentiation during the induced differentiation, Acanthopanacis Cortex(五加皮) of ethyl alcohol-extract has a control effect. Okapijangchek-tang(五加皮壯脊湯)·Acanthopanacis Cortex(五加皮)·Phragmitis Rhizoma(蘆根) of the boiling water-extract have a cyto-toxicity. 4) At the Taeum-In(太陰人)'s prescriptions and herbs on the first-differentiation during the induced differentiation, Coicis Semen(薏苡仁)·Ephedrae Herba(麻黃)·Imperatae Rhizoma(白茅根) of the boiling water-extract and Ephedrae Herba(麻黃) of the ethyl alcohol-extract have a control effect. Kalopanaxii Cortex(海桐皮) of the boiling water-extract and the ethyl alcohol-extract has a cyto-toxicity. Considering this result, the Taeyang-In(太陽人)·Taeum-In(太陰人)'s prescriptions and herbs have a control effect on edipocytes during the proliferation. Acanthopanacis Cortex(五加皮), Coicis Semen(薏苡仁)·Ephedrae Herba(麻黃)·Imperatae Rhizoma(白茅根) have a control effect on edipocytes during the induced differentiation. In the future, for treating a obesity need a vivo assay and hope this study to help to know the mechanisms of obesity.